รศ.ดร.ทพญ.อุรีพร เล็กกัต

รศ.ดร.ทพญ.อุรีพร เล็กกัต

รศ.ดร.ทพญ. อุรีพร  เล็กกัต (เกตจรูญ)

Ureporn  Leggat (Kedjarune), D.D.S., Ph.D.

Current position :   Associate Professor

Education

  • D.D.S., Mahidol University
  • Ph.D. (Tropical Medicine), Mahidol University
  • Grad. Cert. (DNA Technology), Canberra Institute of Technology, Australia

Research Field
Dental biomaterial design for tissue engineering and regenerative medicine

Publication
1. Kedjarune U, Migasena P, Changbumrung S, Pongpaew P and Tungtrongchitr R. Flow rate and composition of whole saliva in children from rural and urban Thailand with different caries prevalence and dietary intake. Caries Research. 1997; 31:148-154.

2. Kedjarune U, Chowanadisai S, Yapong B, Kukiattrakoon B, Leggat PA, Jitsurong S. Quantitative analysis of bacterial aerosals within different types of dental clinics. Journal of the Thai Dental Association. 1998; 48:149-154.

3. Kedjarune U, Charoenworaluk N, Koontongkaew S. Release of methyl methacrylate from heat-cured and autopolymerised resin : cytotoxicity testing related to their residual monomers. Australian Dental Journal. 1999; 44:25-30.

4. Thumvanit V, Kedjarune U. Cytotoxicity of polymerised commercial cyanoacrylate adhesive on culture human oral fibroblasts. Australian Dental Journal. 1999; 44:248-252.

5. Chowanadesai S, Leggat PA, Kukiattrakoon B, Yapong B, Kedjarune U. Occupational health problems of dentists in southern Thailand. International Dental Journal. 2000; 50:36-40.

6. Kedjarune U, Leggat PA, Kukiattrakoon B, Yapong B, Chowanadisai S. Bacterial aerosols in the dental clinic : effect of positioin, time and type of treatment. International Dental Journal. 2000; 50:103-107.

7. Kedjarune U, Pongprerachok S, Arpornmaeklong P, Ungkusonmongkhon K. Culturing primary human gingival epithelial cells : comparison of two isolation techniques. Journal of Cranio-Maxillofacial Surgery. 2001; 29:224-231.

8. Chuajepong P, Kedjarune-Leggat U, Kertpon D, Chongsuvivatwong V, Benjakul P. Associated factors of tooth wear in sounthern Thailand. Journal of Oral Rehabilitatiion. 2002; 29:997-1002.

9. Jarearnsuk P, Pripatnanont P, Wasinanukorn M, Leggat U, Danworanan P, Tintara P. Pain and anxiety control in anxious patients undergoing third molar surgery. Journal of the Thai Dental Association. 2003; 53:366-375.

10. Suttapreyasri S, Koontongkaew S, Phongdara A, Leggat U, Expression of bone morphogenetic proteins in normal human intramembranous and endochondral bones. Journal of Oral and Maxillofac Surgery. 2006; 35:444-452.

11. Choosawad, D., Leggat, U., Dechsukhum, C., Phongdara, A. and Chotigeat, W. Anti-tumour activities of fucoidan from the aquatic plant Utricularia aurea lour songklanakarin J. Sci. Technol., Dec. 2005, 27(Suppl. 3) : 799-807

12. Piangprach T, Hengtrakool C, Kukiattrakoon B, Kedjarune-Leggat U. The effect of salivary factors on dental erosion in various age groups and tooth surfaces. J Am Dent Assoc. 2009;140(9):1137-1143.

13. Limapomvanich A, Jitpukdeebodintra S, Hengtrakool C, Kedjarune-Leggat U. Bovine serum albumin release from novel chitosan-fluoro-aluminosilicate glass ionomer cement: stability and cytotoxicity studies. J Dent. 2009;37(9):686-690.

14. Kukiattrakoon B, Hengtrakool C, Kedjarune-Leggat U. The effect of acidic agents on surface ion leaching and surface characteristics of dental porcelains. J Prosthet Dent. 2010;103(3):148-162.

15. Kukiattrakoon B, Hengtrakool C, Kedjarune-Leggat U. Chemical durability and microhardness of dental ceramics immersed in acidic agents. Acta Odontol Scand. 2010;68(1):1-10.

16. Supaprutsakul S, Chotigeat W, Wanichpakorn S, Kedjarune-Leggat U. Transfection efficiency of depolymerized chitosan and epidermal growth factor conjugated to chitosan-DNA polyplexes. J Mater Sci Mater Med. 2010;21(5):1553-1561.

17. Kukiattrakoon B, Hengtrakool C, Kedjarune-Leggat U. The effect of acidic agents on surface ion leaching and surface characteristics of dental porcelains. J Prosthet Dent. 2010;103(3):148-162.

18. Kukiattrakoon B, Hengtrakool C, Kedjarune-Leggat U. Degradability of fluorapatite-leucite ceramics in naturally acidic agents. Dent Mater J. 2010;29(5):502-511.

19. Hengtrakool C, Kukiattrakoon B, Kedjarune-Leggat U. Effect of naturally acidic agents on microhardness and surface micromorphology of restorative materials. Eur J Dent. 2011;5(1):89-100.

20. Rakkiettiwong N, Hengtrakool C, Thammasitboon K, Kedjarune-Leggat U. Effect of novel chitosan-fluoroaluminosilicate glass ionomer cement with added transforming growth factor beta-1 on pulp cells. J Endod. 2011;37(3):367-371.

21. Wanachottrakul N, Chotigeat W, Kedjarune-Leggat U. Translationally controlled tumor protein against apoptosis from 2-hydroxy-ethyl methacrylate in human dental pulp cells. J Mater Sci Mater Med. 2011;22(6):1479-1487.

22. Hengtrakool C, Kukiattrakoon B, Kedjarune-Leggat U. Gradual surface degradation of restorative materials by acidic agents. Gen Dent. 2011;59(2):e50-e62.

23. Kukiattrakoon B, Hengtrakool C, Kedjarune-Leggat U. Effect of acidic agents on surface roughness of dental ceramics. Dent Res J (Isfahan). 2011;8(1):6-15.

24. Khimmakthong U, Kongmee P, Deachamag P, Leggat U, Chotigeat W. Activation of an immune response in Litopenaeus vannamei by oral immunization with phagocytosis activating protein (PAP) DNA. Fish Shellfish Immunol. 2013;34(3):929-938.

25. Nikom, J, Charoonpatrapong-Panyayong K, Kedjarune-Leggat U, Stevens R, Kosachan N, Jaroenworaluck A. 3D interconnected porous HA scaffolds with SiO2 additions: effect of SiO2 content and macropore size on the viability of human osteoblast cells. Journal of Biomedical Materials Research Part A. 2013; 101(8):2295-2305.

26. Wanachottrakul N, Chotigeat W, Kedjarune-Leggat U. Effect of novel chitosan-fluoroaluminosilicate resin modified glass ionomer cement supplemented with translationally controlled tumor protein on pulp cells. Journal of Material Science Materials in Medicine. 2014; 25(4):1077-1085.

27. Kedjarune-Leggat U, Supaprutsakul C, Chotigeat W. Ultrasound treatment increases transfection efficiency of low molecular weight chitosan in fibroblasts but not in KB cells. PLoS One. 2014; 9(3):e92076.

28. Sangsuwan J, Wanichpakorn S, Kedjarune-Leggat U. Translationally controlled tumor protein supplemented chitosan modified glass ionomer cement promotes osteoblast proliferation and function. Materials Science and Engineering C. 2015; 54: 61-68.

29. Jirachotikoon C, Tannukit S, Kedjarune-Leggat U. Expression of translationally controlled tumor protein in heat-stressed human dental pulp cells. Arch Oral BIol 2015; 60: 1474-1481.

30. Sangsuwan J, Wanichpakorn S, Kedjarune-Leggat U. Translationally controlled tumor protein supplemented chitosan modified glass ionomer cement promotes osteoblast proliferation and function. Mater Sci Eng C 2015; 54:61-68.

31. Jirachotikoon C, Tannukit S, Kedjarune-Leggat U. Expression of translationally controlled tumor protein in heat-stressed human dental pulp cells. Arch Oral Biol 2015; 60:1474-1481.

32. Wongkhum C, Chotigeat W, Kedjarune-Leggat U. Effect of recombinant vascular endothelial growth factor and translationally controlled tumor protein on 2 hydraxyethyl metaacrylate-treted pulp cells. Mal Med Rep 2018 Apr; 17(4):6100-6108.

33. Yodthong T, Kedjarune-Leggat U, Smythe C, Wititsuwannakul R, Pitakpornpreecha T.  I-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway. Molecules 2018; 23, 3086: 1-16.

34. Yodthong T, Kedjarune-Leggat U, Smythe C, Sukprasirt P, Aroonkesorn A, Wititsuwannakul R, Pitakpornpreecha T. Enhancing Activity of Pleurotus sajor-caju (Fr.) Sing b-1,3-Glucanoligosaccharide (Ps-GOS) on Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells through the Involvement of BMP-2/ Runx2/ MAPK/ Wnt/ b-Catenin Signaling Pathway. Biomolecules 2020 Jan 27;10(2):190.doi: 10.3390/ biom10020190.

35. Kedjarune-Leggat U, Saetan U, Khongsaengkaeo A, Suwannarat S, Deachamag P, Wonglapsuwan M, et al. Biological activities of a recombinant fortilin from Fenneropenaeus merguiensis. PLoS ONE 2020; 15(10): e0239672. https:// doi.org/10.1371/journal.pone.0239672.

36. Pitakpornpreecha T, Leggat U, Wititsuwannakul R, Smythe C, Yodthongt T, Sukprasirt P and Aroonkesorn A. Enhancing Activity of PleurotusSajor-Caju (FR.) Sing BETA-1,3-Glucanoligosaccharide (PS-GOS) on Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells through the Involvement of BMP-2/RUNX2/MARK/WNT/BETA-CATENIN Signaling Pathway. Biomolecules 2020 (Jan); 10:1-16.

37. Sangsuwan P, Chotigeat W, Tannukit S, Kedjarune-Leggat U. Long-Term Effect of Modified Glass Ionomer Cement with Mimicked Biological Property of Recombinant Translationally Controlled Protein. Polymers 2022; 14, 3341. https://doi.org/10.3390/polym14163341.

38. Sangsuwan P, Tannukit S, Chotigeat W, Kedjarune-Leggat U. Biological Activities of Glass Ionomer Cement Supplemented with Fortilin on Human Dental Pulp Stem Cells. Journal of Functional Biomaterials 2022; 13 (3), 132. https://doi.org/10.3390/jfb13030132.

39. Chumpraman, A., Tannukit, S., Chotigeat, W., Kedjarune-Leggat, U. Biocompatibility and mineralization activity of modified glass ionomer cement in human dental pulp stem cells. Journal of Dental Sciences. 2023; 18(3):1055-1061.

40. Hengtrakool C, Wanichpakorn S, Kedjarune-Leegat U. Chitosan Resin-Modified Glass Ionomer Cement Containing Epidermal Growth Factor Promotes Pulp Cell Proliferation with a Minimum Effect on Fluoride and Aluminum Release. Polymers 2023; 15(17), 3511. https://doi.org/10.3390/polym15173511.

สิทธิบัตร/อนุสิทธิบัตร

1. เรื่อง วัสดุสำหรับการปลดปล่อยสารของกลาสไอโอโนเมอร์ซีเมนต์ประยุกต์ด้วยไคโตซาน ได้รับการจดสิทธิบัตร  เมื่อ วันที่ 31 เดือนมกราคม พ.ศ. 2566 เลขที่ 0501002755

2. เรื่อง ส่วนผสมของเรซิน ประยุกต์กลาสไอโอโนเมอร์ซีเมนต์และกรรมวิธีการผลิตส่วนผสมดังกล่าว ได้รับการจดสิทธิบัตร เมื่อวันที่ 13 เดือนมีนาคม พ.ศ. 2566  เลขที่ 1001001095

3. เรื่อง กรรมวิธีการผลิตโปรตีนลูกผสมฟอติลิน ได้รับการจดอนุสิทธิบัตร เมื่อวันที่ 4 เดือนเมษายน พ.ศ.2566 เลขที่คำขอ 2003002673

4. เรื่อง ผลิตภัณฑ์เรซิน ประยุกต์กลาสไอโอโนเมอร์ซีเมนต์ด้วยไคโตซานและอัลบูมิน ได้รับการจดสิทธิบัตร เมื่อวันที่  8 เดือนมกราคม พ.ศ.2567  เลขที่ 0901005864

PROCEEDING
1. Koontongkaew, S., Kedjarune, U., Jitpukdeebodintra, S., Pongprerachok, S. and Kumplanont, P. Ultrastructure of Primary Culture Cells from Human Ameloblastoma. (Abstract) In : Proceedings of the Annual Scientific Meeting of the Dental Research Association of Thailand, Bangkok, Thailand, 1995.
2. Kedjarune U, Pongprerachok S, Arporkmaeklong P, and Ungkusonmongkhon K. Using direct explant method to cultivate human gingival epithelial cells. 78th General Session of the International Association for Dental Research, Washington DC, USA, 2000; Abstract # 1429 Journal of Dental Research. 2000; 79 (Suppl) Abstract # 1429:322.
3. Chotigeat, W., Kedjarune-Leggat, U, Tonganum, M and Pongprerachok-Wanichpakorn. Production of Epidermal Growth Factro. In: 27th Congress on Science and Technology of Thailand. Hat Yai, Songkhla, Thailand, 2001; Abstract #17-16 p-82:582.
4. Kedjarune-Leggat U, Chotigeat W, Wanichpakorn S. and Sealim K. Transfection Efficiency in Electroporation of HaCaT Cells. (Abstract Proceeding of The 19th International Association for Dental Research, 15th South-East Asia Association for Dental Education, Annual Scientific Meeting, Imperial Boathouse, Koh Samui, Surattany, Thailand, 3-6 September 2004; (Supply) Abstract # IP-031-91.
5. Kedjarune U, Chotigeat W, Wanichpakorn S, Human EGF gene transfection in Ha CaT cells and its bioactivity (Abstract Proceeding of The 84th General Session & Exhibition of the IADR 1st Meeting of the Pan-Asian-Pacific Federation, Brisbane Convention & Exhibition Centre BRISBANE, Australia, 28 June – 1 July 2006; Abstract # 0971.
6. Hengtrakool C, Piangprach T, Kukittrakoon B, Kedjarune U, Salivary Potential to Neutralize an Acidic Juice (Abstract Proceeding of The 84th General Session & Exhibition of the IADR 1st Meeting of the Pan-Asian-Pacific Federation, Brisbane Convention & Exhibition Centre BRISBANE, Australia, 28 June – 1 July 2006; Abstract # 1835.
7. Supaprutsakul S, Chotigeat W, Wanichpakorn S. and Kedjarune U, The transfection efficiency of two different molecular weights of chitosan in KB cells (Abstract Proceeding of The 6th Princess Chulabhorn International Science Congress The interface of chemistry and biology in the “OMICS” ERA: Environment & Health and drug discovery Bangkok, Thailand, 25-29 November 2007; Volume II, Abstract # PN-11. p.158-159.
8. Nikom J, Panyayong K, Joenworaluck A, Kosachan N. and Leggat U, Cell Cytotoxicity of Silica Doped Hydroxyapatite Bio-ceramics to Bone Cell. (Abstract Proceeding of The 34th Congress on Science and Technology of Thailand. Bangkok, Thailand, 31 October – 2 November 2008; Abstract # I-I0011 p.268.
9. Wanachoattrakul N, Chotigeat W. and Leggat U, The Effect of The Translationally Controlled Tumor Protein Against Cytotoxicity of 2-Hydroxyethyl Methacrylate On Human Dental Pulp Cells. (Abstract Proceeding of The 34th Congress on Science and Technology of Thailand. Bangkok, Thailand, 31 October – 2 November 2008; Abstract # I-I0010 p.268.
10. Naowapradab J, Wattanaroonwong N, Jitpukdeebodintra S. and Leggat U, Effects of Porphyromnas Gingivalis Lipopolysaccharide on Human Gingival Fibroblasts (Abstract Proceeding of The 34th Congress on Science and Technology of Thailand. Bankok, Thailand, 31 October – 2 November 2008; Abstract # I-I004 p.266.
11. Wanachoattrakul N, Chotigeat W. and Leggat U, Effect of Translationally Controlled Tumor Protein against Cell Death from 2-Hydroxyethyl Methacrylate in Human Dental Pulp Cells. (Abstract Proceedings of the RGJ-Ph.D. Congress X. Jomtrean Plam Beach Resort Hotel, Pattaya, Chonburi, 3-5 April 2009.

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